Table 2.

Correlation matrix of mediators that regulate aromatase expression

 COX-2 mRNACOX-2 proteinPGE2 levelcAMP levelPKA activityAromatase expressionAromatase PI.3Aromatase PIIAromatase activityPR protein
CLS-B index0.600.830.850.830.790.750.660.710.880.91
COX-2 protein0.69
PGE2 level0.620.83
cAMP level0.640.890.96
PKA activity0.630.820.940.90
Aromatase expression0.600.620.740.620.65
Aromatase PI.30.420.57*0.54*0.51*0.51*0.58*
Aromatase PII0.450.620.590.600.610.730.87
Aromatase activity0.57*0.750.820.850.760.600.630.64
PR protein0.410.710.780.730.730.600.52*0.55*0.731.0
  • NOTE: Each number represents the Spearman's rank correlation coefficient of the levels of the 2 corresponding mediators in the study population. Most of the correlation coefficients are statistically significantly different from 0 (P < 0.001, *P < 0.01, P < 0.05, P ≥ 0.05).

  • Abbreviations: BMI, body mass index; cAMP, cyclic AMP; CLS-B, crown-like structures of the breast; COX, cyclooxygenase; PKA, protein kinase A; PR, progesterone receptor.