Table 1.

Proteins highly expressed or dysregulated in SCLCs

ProteinRatio SCLC:NSCLC mean expressionF statisticPPathway
Rb/E2F1 pathway
 Rb0.3990.69<2.2E-16Rb/E2F1 pathway (lower SCLC)
 Rb (Ab2)0.6186.38<2.2E-16Rb/E2F1 pathway (lower SCLC)
 Rb (Ab2)0.6082.93<2.2E-16Rb/E2F1 pathway (lower SCLC)
 Rb_pS807/8110.4094.65<2.2E-16Rb/E2F1 pathway (lower SCLC)
 E2F10.49198.66<2.2E-16Rb/E2F1 pathway (higher SCLC)
 Cyclin D10.6775.432.22E-16Rb/E2F1 pathway (higher SCLC)
 Cyclin D1 (Ab2)0.51134.55<2.2E-16Rb/E2F1 pathway (higher SCLC)
 p162.1395.65<2.2E-16Rb/E2F1 pathway (higher SCLC)
 p211.7835.089.02E-09Rb/E2F1 pathway (higher SCLC)
 EZH21.5089.58<2.2E-16Rb/E2F1 pathway (higher SCLC)
 Thymidylate synthase1.4539.551.19E-09Rb/E2F1 pathway (higher SCLC)
 Cyclin E11.3323.402.15E-06Rb/E2F1 pathway (higher SCLC)
Apoptosis
 PARP1 (cleaved)4.25332.36<2.2E-16Apoptosis
 Bcl-24.03357.05<2.2E-16Apoptosis
 BIM2.58170.82<2.2E-16Apoptosis
 Bax1.64131.27<2.2E-16Apoptosis
DNA repair
 PARP1 (total)2.10137.98<2.2E-16DNA repair
 53BP11.9974.933.33E-16DNA repair
 DNA PKcs1.6934.351.26E-08DNA repair
 ATM1.5918.901.91E-05DNA repair
 PCNA1.5673.606.66E-16DNA repair
 ChK21.5124.891.05E-06DNA repair
 Total PARP1 (Ab2)1.44135.67<2.2E-16DNA repair
 XRCC11.4372.937.77E-16DNA repair
 MSH21.4031.873.97E-08DNA repair
 RAD501.3222.663.08E-06DNA repair
 pATR1.3149.131.71E-11DNA repair
 ChK11.2927.632.87E-07DNA repair
 4EBP1_pS651.2618.062.90E-05DNA repair
 BRCA11.2431.335.08E-08DNA repair
 4EBP1_pST37/461.238.953.02E-03DNA repair
 pChK11.2215.918.45E-05DNA repair
 TAU1.2177.052.22E-16DNA repair
AMPK pathway
 LKB11.4258.822.70E-13AMPK pathway
 AMPKa_pT1721.4127.962.46E-07AMPK pathway
 TSC2_pT14621.168.274.33E-03AMPK pathway
Other SCLC markers
 Stathamin3.19409.19<2.2E-16Mitosis/cell cycle
 c-Kit9.68237.28<2.2E-16RTK
 IGFBP24.35276.98<2.2E-16 
 c-Myc_pT581.3593.38<2.2E-16c-Myc
 SMAD3_pS4232.23139.91<2.2E-16 
 Src (total)1.9490.72<2.2E-16 
 SGK_pS781.54128.32<2.2E-16