Table 2.

Proteins highly expressed or dysregulated in NSCLCs

ProteinRatio NSCLC:SCLC mean expressionF statisticPPathway
PI3K/Akt pathway
 p70s6k_pT3891.3122.443.42E-06PI3K/Akt pathway
 S61.4350.449.72E-12PI3K/Akt pathway
 Akt_pS4731.5112.285.32E-04PI3K/Akt pathway
 S6_pS240/2422.72118.15<2.2E-16PI3K/Akt pathway
 S6_pS235/2363.18161.86<2.2E-16PI3K/Akt pathway
 GSK3ab0.65124.66<2.2E-16Inhibited by PI3K/Akt pathway
EGFR pathway/RTK
 EGFR1.6684.38<2.2E-16EGFR pathway/RTK
 EGFR_pY11731.6726.784.30E-07EGFR pathway/RTK
 Her2_pY12481.4534.571.14E-08EGFR pathway/RTK
 IRS11.7779.78<2.2E-16EGFR pathway/RTK (associated with intracellular portion of EGFR RTK)
 Axl1.7814.921.39E-04EGFR pathway/RTK
 pAxl Y7791.315.681.78E-02EGFR pathway/RTK
 Met2.6574.294.44E-16EGFR pathway/RTK
 pMet_Tyr1234/12353.2929.111.43E-07EGFR pathway/RTK
 MACC11.6639.231.37E-09EGFR pathway/RTK (transcription factor of cMet)
 VEGFR23.55167.83<2.2E-16EGFR pathway/RTK
JAK/Src/STAT
 STAT6_pY6411.2912.095.85E-04JAK/Src/STAT
 STAT3_pY7051.4426.205.64E-07JAK/Src/STAT
 STAT3_pY705 (Ab2)1.4953.952.14E-12JAK/Src/STAT
 STAT5_pY6941.4923.472.08E-06JAK/Src/STAT
 STAT3_pT7271.5161.339.41E-14JAK/Src/STAT
 STAT33.29156.43<2.2E-16JAK/Src/STAT
Ras/Raf/MEK/MAPK
 pERK1/21.9035.059.14E-09Ras/Raf/MEK/MAPK
 MAPK_pT202/2041.9329.301.31E-07Ras/Raf/MEK/MAPK
Wnt/Hedgehog/Notch
 β-Catenin1.7525.707.14E-07Wnt/Hedgehog/Notch
 Notch31.8754.991.37E-12Wnt/Hedgehog/Notch
 E-Cadherin1.9625.627.45E-07Wnt/Hedgehog/Notch
 PTCH1.98170.65<2.2E-16Wnt/Hedgehog/Notch
Other epithelial markers
 Caveolin3.0745.647.91E-11 
 Fibronectin2.0119.761.25E-05 
 PAI.11.9924.761.12E-06 
Other NSCLC markers
 COX21.9080.33<2.2E-16 
 c-Myc1.6532.902.46E-08 
 ATR1.6110.481.35E-03