Table 1.

Inhibition of cell growth by neratinib and lapatinib

IC50 (nmol/L)
NeratinibLapatinib
MCF10A - HER2 WT<2400 ± 60
 G309A<2470 ± 50
 V777L<21,040 ± 570
 D769H<2980 ± 950
 V842I<2650 ± 210
 del.755–7592.1 ± 0.2660 ± 90
 L755S15 ± 6>10,000
BT474 cells<231 ± 2
MCF7 cells>3,000>10,000

NOTE: Cells were incubated with drugs for 6 days, and cell viability and number were measured using Alamar Blue.