Table 1.

HNSCC tumors with multiple mutations in a single mitogenic pathway

PathwayTumorAnnotated genesAmino acid changeTNM stage/overall staging
PI3K pathwayHN_00190PIK3C2Gp.V656LT1N2bM0/stage IV
PTENp.D92E
HN_62421PIK3R1p.D560HT4N0M0/stage IV
MTORp.L2260H
HN_62469PIK3CAp.H1047RT2N2bM0/stage IV
MTORp.R1161Q
HN_63039PIK3CAp.H1047LT4N2bM0/stage IV
PTENp.R335*
HN_22PTPIK3CGp.G491ET4aN2bM0/stage IV
PIK3AP1p.G313R
HNPTS_1PTENp.R14ST4N0M0/stage IV
PIK3IP1p.A144S
PIK3CAp.E545K
HNPTS_29PIK3C2Gp.S1272LT4N2bM0/stage IV
PIK3R5p.E322K
PIK3CAp.E542K
HNPTS_38PIK3R5p.E60*T4N2M0/stage IV
PIK3CAp.H1047R
HNPTS_42TSC2p.S1514*T4N2BM0/stage IV
PIK3CAp.E545K
PIK3CGp.A156V
HNPTS_45AKT2p.Y351CT4N1M0/stage IV
PIK3CAp.H1047R
JAK/STAT pathwayHN_63080JAK3p.R948CT4aN2bM0/stage IV
STAT1p.Q330K
MAPK pathwayNone

NOTE: The table describes all tumors in our cohort harboring mutations in more than one gene in a defined mitogenic pathway by mutation type and pathologic stage. *, nonsense mutation (mutation to a stop codon)

Abbreviation: TNM, tumor–node–metastasis.