Table 1.

Drug classes and drugs represented in the DSRT screening platform

Classes of drugsDrugs
Alkylating agentsAltretamine, azacitidine, busulfan, carboplatin, carmustine, chlorambucil, cyclophosphamide, dacarbazine, ifosfamide, lomustine, pipobroman, procarbazine, streptozocin, temozolomide, thioTEPA, uracil mustard
AntimetabolitesAllopurinol, capecitabine, cladribine, clofarabine, cytarabine, decitabine, floxuridine, fludarabine, fluorouracil, gemcitabine, mercaptopurine, methotrexate, nelarabine, pentostatin, thioguanine
AntimitoticsABT-751, docetaxel, indibulin, ixabepilone, paclitaxel, patupilone, S-trityl-L-cysteine, vinblastine, vincristine, vinorelbine
Antitumor antibioticsBleomycin, dactinomycin, mitomycin C, plicamycin
BCL-2 inhibitorsNavitoclax, obatoclax
HDAC inhibitorsBelinostat, CUDC-101, entinostat, panobinostat, tacedinaline, vorinostat
Hormone inhibitorsAbiraterone, aminoglutethimide, anastrozole, exemestane, finasteride, flutamide, fulvestrant, goserelin, letrozole, megestrol acetate, nilutamide, raloxifene, tamoxifen
HSP90 inhibitorsAlvespimycin, BIIB021, NVP-AUY922, tanespimycin
ImmunomodulatorsCelecoxib, dexamethasone, fingolimod, imiquimod, lenalidomide, levamisole, methylprednisolone, plerixafor, prednisolone, prednisone, tacrolimus, thalidomide
Kinase inhibitors, AGCAlisertib, AT9283, AZD1152-HQPA, BI2536, bryostatin 1, danusertib, enzastaurin, fasudil, midostaurin, MK-2206, ruboxistaurin, sotrastaurin, UCN-01
Kinase inhibitors, CAMKAZD7762, PF-00477736
Kinase inhibitors, CK1MK-1775
Kinase inhibitors, CMGCAlvocidib, AZ 3146, doramapimod, palbociclib, seliciclib, SNS-032
Kinase inhibitors, PIKLAZD8055, dactolisib, idelalisib, OSI-027, PF-04691502, pictilisib, XL147, XL765
Kinase inhibitors, STEPimasertib, refametinib, selumetinib, trametinib
Kinase inhibitors, TKAfatinib, axitinib, BMS-754807, canertinib, cediranib, crizotinib, dasatinib, dovitinib, EMD1214063, erlotinib, foretinib, gandotinib, gefitinib, imatinib, lapatinib, lestaurtinib, linsitinib, masitinib, MGCD-265, motesanib, nilotinib, pazopanib, ponatinib, quizartinib, regorafenib, ruxolitinib, saracatinib, sorafenib, sunitinib, tandutinib, tivozanib, tofacitinib, vandetanib, vatalanib
Kinase inhibitors, TKLVemurafenib
PARP inhibitorsIniparib, olaparib, rucaparib, veliparib
Proteasome inhibitorsBortezomib, carfilzomib
RapalogsEverolimus, sirolimus, temsirolimus
Smoothened (Hh) inhibitorsErismodegib, vismodegib
Topoisomerase I/II inhibitorsAmonafide, camptothecin, daunorubicin, doxorubicin, etoposide, idarubicin, irinotecan, mitoxantrone, teniposide, topotecan, valrubicin
Miscellaneous antineoplasticsBexarotene, hydroxyurea, mitotane, tretinoin
Other2-Methoxyestradiol, anagrelide, bimatoprost, pilocarpine, Prima-1 Met, serdemetan, tarenflurbil, tipifarnib, XAV-939, YM155

Abbreviations: AGC: PKA, PKG, and PKC kinase group; CAMK: calcium/calmodulin–dependent protein kinase group; CK1: casein kinase group; CMGC: CDK, MAPK, GSK3, and CLK kinase group; PIKL: phosphoinositide 3-kinase (PI3K)-like (PI3K inhibitors and inhibitors of related atypical kinases: mTOR, DNA-PK, ATM, ATR); STE: sterile kinase group; TK: tyrosine kinase group; TKL: tyrosine kinase-like group.