Table 1.

Comparison of methylation heterogeneity with patient characteristics and prognostic indicators

Low DNA methylation heterogeneity no. (%)High DNA methylation heterogeneity no. (%)P
Patient characteristics
 Age at diagnosis (y ± SD)55.8 ± 11.859.9 ± 10.6n.s.
 Sex (female)10 (33)15 (48)n.s.
 Pretreatment (yes)6 (19)13 (42)0.014
Prognostic indicators
IGHV unmutated8 (35)11 (79)<0.01
ZAP70 low methylation7 (30)9 (69)0.024
 Cytogenetics (NK, sole -13q)14 (61)9 (69)n.s.

Abbreviation: n.s., not significant.