Table 1.

Ceritinib is a potent ALK inhibitor

GI50 (nmol/L)
CrizotinibCeritinibFold
ALK enzymatic assay30.1520
H22281073.828
H31222456.339

NOTE: GI50 values for in vitro ALK enzymatic assay or H3122 and H2228 cell survival assay for crizotinib and ceritinib are shown.