Table 1.

Influence of Tmprss2 expression on the frequency of prostate cancer metastasis

Recipients with metastasesa
Donor age (wks)Donor genotype (# donors)LiverLung
12Tmprss2+/+(n = 2)0/90/9P = nsb
TRAMP
Tmprss2−/−(n = 1)0/30/3
TRAMP
20Tmprss2+/+(n = 2)9/97/9P < 0.001
TRAMP
Tmprss2−/−(n = 4)0/150/15
TRAMP
32Tmprss2+/+(n = 5)21/2119/21P < 0.001
TRAMP
Tmprss2−/−(n = 6)0/280/28
TRAMP
  • aNumber of recipient mice with metastasis/number of total recipient mice.

  • bComparison of the frequency of metastasis between donor genotypes.