Table 2.

Risk estimates and predicted miRNAs for the 22 putative miRSNPs associated with prostate cancer risk

miRSNPGeneTranscript variantaPredicted miRNA(s)bchrPositionRisk OR (95% CI)cRisk P value
rs4245739MDM4dNM_002393, NM_001204171, NM_001204172miR-191-5p, miR-887, miR-366912045188420.92 (0.89–0.95)7.81E−08
rs4233979TMEM17NM_198276miR-299-5p2627279021.08 (1.04–1.12)1.61E−05
rs1010VAMP8eNM_003761miR-370, miR-1032858089820.91 (0.89–0.94)3.79E−11
rs17664ITGA6eNM_001079818, NM_000210miR-548c-3p, miR-548aj, miR-4691-3p21733692310.93 (0.91–0.96)5.51E−07
rs1530865PDK1NM_002610miR-877-5p, miR-3125, miR-391621734610900.8 (0.75–0.86)2.28E−09
rs2357637PDK1NM_002610miR-3916, miR-3125, miR-877-5p21734631380.81 (0.76–0.88)3.66E−08
rs7615039PHC3NM_024947miR-208a, miR-208b31698061700.86 (0.83–0.9)8.72E−12
rs12492606PHC3NM_024947miR-939, miR-362-5p31698083540.86 (0.83–0.9)1.23E−11
rs879161PHC3NM_024947miR-27a-5p, miR-220c, miR-3158-3p31698121150.86 (0.83–0.9)6.57E−12
rs14082PDLIM5eNM_006457, NM_001011513, NM_001256425, NM_001256426, NM_001256428miR-128, miR-4944955862241.09 (1.06–1.12)1.27E−09
rs1043853PDLIM5eNM_006457, NM_001011513, NM_001256425, NM_001256426, NM_001256427, NM_001256428miR-567, miR-3120, miR-43104955882741.08 (1.05–1.11)9.65E−09
rs2647257TET2eNM_001127208miR-301a, miR-301b, miR-433041061995051.1 (1.06–1.13)2.05E−10
rs2450975SLC22A2eNM_003058, NM_003058miR-412, miR-428261606379751.12 (1.09–1.16)9.36E−13
rs3127593SLC22A2eNM_003058miR-200a, miR-302a, miR-488-3p61606380031.12 (1.08–1.17)2.22E−08
rs3103353SLC22A2eNM_003058miR-942, miR-426861606380761.12 (1.08–1.17)1.75E−08
rs1810126SLC22A3eNM_021977miR-1205, miR-124-3p, miR-216b61608721511.1 (1.07–1.13)2.81E−11
rs1567669NKX3-1eNM_006167, NM_001256339miR-637, miR-1275, miR-6258235385331.11 (1.08–1.15)3.15E−13
rs12573077ARL3NM_004311miR-432, miR-1258, miR-1224-5p101044346300.93 (0.91–0.96)6.43E−06
rs1058205KLK3dNM_001648, NM_001030047, NM_001030048miR-3162-5p, miR-219-1-3p, miR-427819513633980.87 (0.83–0.9)1.73E−14
rs311497GMEB2NM_012384miR-26c, miR-492, miR-619, miR-464820622212490.92 (0.89–0.94)1.28E−09
rs7402MCATNM_173467, NM_014507miR-616-3p22435290290.93 (0.91–0.96)4.41E−06
rs47340TTLL12NM_015140let-7f, let-7g, let-7i, miR-103, miR-107, miR-76422435628291.07 (1.04–1.1)5.79E−06
  • amiRSNPs are present within the 3′UTRs of the most common splice variants of the miRNA target genes.

  • bmiRNAs were predicted using four algorithms (Methods).

  • cadjusted for 6 principal components and study group.

  • dSNP previously identified in prostate cancer GWAS and fine-mapping studies.

  • eOther SNPs within or around the genes for the listed SNPs have been identified in previous GWAS studies.