Table 1.

Cotransplantation of CD29hiCD24lo putative niche cells with TICs

(A) Cells cotransplantedEfficiency of tumor formation (number of tumors formed/transplants)Latency of tumor formation, wk (palpable ∼2–3 mm)
Niche cells (CD29hiCD24lo)TICs (CD29hiCD24hi)
050/8
1022/821, 27
1000/8
0102/817,19
2104/814,19,23,25
10106/88,12,13,15,17,27
0203/814,16,19
10206/88,8,10,12,13,15
(B) Cells cotransplantedEfficiency of tumor formation (number of tumors formed/transplants)Latency of tumor formation, wk (palpable, ∼2–3 mm)
Ctrl shRNA-transduced niche cells (CD29hiCD24lo)WNT-responsive cells (GFP+)
0101/418
2000/4
2101/415
10103/49,11,11
20104/48,8,11,11
Cells cotransplantedEfficiency of tumor formation (number of tumors formed/transplants)Latency of tumor formation, wk (palpable, ∼2–3 mm)
Wnt2 shRNA-transduced niche cells (CD29hiCD24lo)WNT-responsive cells (GFP+)
0101/420
2000/4
2101/420
10101/415
20102/413,15