Table 2.

Clinical biomarkers related to CRS, by grade (N = 51)

Total cohortChildrenAdults
BiomarkerTotal cohort (N = 51)Grade 0–3 (N = 37)Grade 4–5 (N = 14)Grade 0–3 (N = 28)Grade 4–5 (N = 11)Grade 1–3 (N = 9)Grade 4–5 (N = 3)
Ferritin (ng/mL)23,439 (280–411,936)8,290 (280–411,936)**,a130,000c(11,200–299,000)**,a4,455 (280–411,936)**123,000 (11,200–299,000)**35,246 (2,191–220,657)a>100,000, 266,190, 234,811a,b
LDHd (U/L)1,673 (158–23,778)852 (158–19,104)*5,594 (1,648–23,778)*881 (545–19,104)*5,898 (1,697–23,778)*679 (158–9,581)1,902 (1,648–7,386)
CRPd (mg/dL)20.1c (0.7–56.5)16.2 (0.7–56.5)*,a22.9c(>16.0–37.1)*,a14.7 (0.7–56.5)*26.6 (20.2–37.1)*22.4 (12.2–32.0)a>16, 17.1, 22.9a,b
ALT (U/L)107 (26–1,238)95 (26–748)198 (50–1,238)82 (29–748)190 (50–1,238)146 (26–396)284 (84–504)
AST (U/L)149 (19–1,427)103 (19–1,424)**389 (98–1,427)**98 (35–1,060)**318 (119–1,427)**103 (19–1,424)867 (98–938)
BUN (mg/dL)18 (9–202)17 (9–72)**44 (12–202)**17 (9–54)*42 (12–202)*17 (11–72)55 (31–61)
Cr (mg/dL)0.7 (0.2–5)0.7 (0.2–4)*1 (0.4–5)*0.5 (0.2–1.7)*0.9 (0.4–3.4)*0.9 (0.7–4)1.8 (1.04–4.95)
Fibrinogen mind (mg/dL) <150 N (%)18/36 (50%)7/23 (30%)*11/13 (85%)*2/15 (13%)**9/10 (90%)**5/8 (63%)2/3 (67%)
Fibrinogen mind(mg/dL)159 (23–624)241 (23–624)**77 (23–221)**288 (93–624)**76 (23–221)**124 (23–278)128 (64–175)
PT (sec)17.1 (13.5–45.4)15.7 (13.5–27.5)**23.1 (17.1–45.4)**15.1 (13.5–20.6)**24.4 (17.1–33.7)**18.0 (14.5–27.5)19.3 (17.7–45.4)
PTT (sec)44.1 (25.7–92.0)39.8 (25.7–64.4)*54.2 (37.2–92.0)*34.4 (25.7–64.4)**58.1 (40.6–92.0)**44.1 (32.4–58.1)43.5 (37.2–52.2)
  • NOTE: Unless otherwise noted, the median (range) for the peak observed value over 1 month is displayed.

  • Abbreviations: Cr, creatinine; PT, prothrombin time; PTT, partial thromboplastin time.

  • P < 0.05 (bold); *, P < 0.01, **, P < 0.001. Peaks or min: exact Wilcoxon for continuous; Fisher exact for discrete.

  • aWilcoxon test for right-censored data.

  • bActual values.

  • cEstimated from the Kaplan–Meier curve due to censored data at the upper limit of detection.

  • dTotal N = 50, 49, 36, 39, and 38 for LDH, CRP, Fibrinogen, PT, and PTT respectively.