Table 1.

Clinical factors related to cytokine release syndrome, by grade (N = 48)

Total cohortChildren (age <25)Adults (age ≥25)
Clinical factorTotal cohort (N = 48)Grade 1–3 (N = 34)Grade 4–5 (N = 14)Grade 1–3 (N = 25)Grade 4–5 (N = 11)Grade 1–3 (N = 9)Grade 4–5(N = 3)
Days to CRS
 Start1 (0–10)2.5 (0–10)1 (0–6)4 (0–10)*1 (0–2)*1 (0–7)1 (0–6)
 Stop10 (5–24)9 (5–24)11.5 (5–16)9 (5–24)*11 (9–15)*10 (6–20)15 (5–16)
Days to fever (N = 41):
 Start1 (0–10)2 (0–10)1 (0–6)4 (0–10)1 (0–2)1 (0–7)2 (0–6)
 Stop8 (5–23)8 (5–23)9 (5–15)7 (5–23)8 (5–12)8 (6–13)13 (5–15)
 Total days febrile6 (1–17)6 (1–17)8 (3–13)5 (1–17)7 (3–12)6.5 (6–10)9 (3–13)
Intubation
 Yes9 (19%)0 (0%)9 (64%)0 (0%)6 (55%)0 (0%)3 (100%)
 No39 (81%)34 (100%)**5 (36%)**25 (100%)**5 (45%)**9 (100%)*0 (0%)*
Days to intubation
 Start6 (3–13)6 (3–13)6 (4–10)10 (3–13)
 Stop15 (5–66)15 (5–66)15 (10–66)15 (5–16)
Vasoactives
 Yes20 (42%)6 (18%)14 (100%)3 (12%)11 (100%)3 (33%)3 (100%)
 No28 (58%)28 (82%)**0 (0%)**22 (88%)**0 (0%)**6 (67%)0 (0%)
Days to vasoactives
 Start5 (1–13)4.5 (1–7)5 (2–13)7 (2–7)5 (2–10)3 (1–6)10 (4–13)
 Stop10 (2–16)8 (2–10)10.5 (5–16)9 (8–10)10 (8–14)5 (2–8)15 (5–16)
Encephalopathy
 Yes13 (27%)5 (15%)8 (57%)5 (20%)8 (73%)0 (0%)0 (0%)
 No34 (71%)29 (85%)*5 (36%)*20 (80%)*2 (18%)*9 (100%)3 (100%)
 Unknown1 (2%)0 (0%)1 (7%)0 (0%)1 (9%)
Infection
 Yes6 (13%)2 (6%)4 (29%)2 (8%)2 (18%)0 (0%)2 (67%)
 No42 (88%)32 (94%)10 (71%)23 (92%)9 (82%)9 (100%)1 (33%)
  • NOTE: Continuous variables are summarized as median (range) and categorical variables as number (percent). Event timing is provided as time since infusion in days.

  • P < 0.05 (bold); *, P < 0.01; **, P < 0.001. Days: exact Wilcoxon; categorical: Fisher exact (Unknown category not included in calculation).