Table 1.

New associations with a second cancer at known single-cancer risk locia

Region, positionbIndex SNP, nearest geneAlleles (E/R), EAFCancer typeOR (95% CI)PImputation r2c
New associations with breast cancer at known index SNPs for ovarian or prostate cancer (same direction)
9q34rs635634T/CBreast cancer1.06 (1.03–1.08)8.1 × 10−70.88
136155000ABO0.20Ovarian cancer1.12 (1.07–1.16)8.6 × 10−90.88
3q23rs6763931dA/GBreast cancer1.04 (1.02–1.06)1.2 × 10−61f
141102833ZBTB380.45Prostate cancer1.06 (1.03–1.08)1.0 × 10−61f
11q23rs11214775A/GBreast cancer0.96 (0.94–0.98)5.2 × 10−50.82
113807181HTR3B0.29Prostate cancer0.93 (0.90–0.95)3.0 × 10−80.82
New association with ovarian cancer at a known index SNP for breast cancer (same direction)
13q13rs11571833dT/AOvarian cancere1.57 (1.33–1.85)6.4 × 1081f
32972626BRCA20.008Breast cancere1.46 (1.23–1.73)6.9 × 10−61f
New association with prostate cancer at a known index SNP for breast cancer (opposite direction)
2q33rs1830298T/CProstate cancer1.06 (1.04–1.09)1.3 × 10−60.99
202181247ALS2CR120.71Breast cancer0.94 (0.93–0.96)2.6 × 10−100.99
  • Abbreviations: (E/R), (effect/reference) alleles; EAF, effect allele frequency.

  • aThe new associations are in bold text and listed first.

  • bBuild 37 coordinates.

  • cImputation accuracy, r2, in iCOGS European samples.

  • dPreviously published genome-wide significant associations for rs6763931 (prostate cancer) and rs11571833 (breast cancer) did not reach P < 5 × 10−8 in the data sets used for the current study.

  • eResults reported here are for ER-negative breast cancer and serous invasive ovarian cancer as the effect size estimates (odds ratios) were larger for the subtype-specific associations when compared to overall breast cancer and all invasive ovarian cancer.

  • fGenotyped SNP.