Table 4.

Treatment-emergent AEs

AE, n (%)aAny grade AEGrade 3/4 AE
Any AE32 (100)26 (81)
 Nausea19 (59)2 (6)
 Diarrhea18 (56)2 (6)
 Hypokalemia13 (41)7 (22)
 Vomiting13 (41)0
 Fatigue11 (34)0
 Headache11 (34)1 (3)
 Hypomagnesemia11 (34)0
 Febrile neutropenia10 (31)10 (31)
 Hypophosphatemia10 (31)2 (6)
 Abdominal pain9 (28)2 (6)
 Cough9 (28)0
 Epistaxis8 (25)2 (6)
 Hyperphosphatemia8 (25)0
 Hypocalcemia8 (25)3 (9)
 Pneumonia8 (25)6 (19)
 Dyspnea7 (22)0
 Hypotension7 (22)4 (13)
 Peripheral edema7 (22)0
 Pyrexia7 (22)1 (3)
 Insomnia5 (16)1 (3)
 Urinary tract infection5 (16)4 (13)
Serious AE, n (%)bTotal
Any serious AE27 (84)
 Febrile neutropenia9 (28)
 Pneumonia5 (16)
 Abdominal pain2 (6)
 Acute renal failure2 (6)
 Failure to thrive2 (6)
 Hypotension2 (6)
 Sepsis2 (6)
 Urinary tract infection2 (6)
  • aAEs occurring in ≥10% of patients regardless of cause; excludes 9 AEs of disease progression of AML.

  • bSerious AEs occurring in at least 2 patients regardless of cause; excludes serious AEs of disease progression of AML.