Table 1.

Benefits of neoadjuvant endocrine therapy

Avoidance of surgery in frail/older patients
Alternative to neoadjuvant chemotherapy in selected patients
Breast-conserving surgery
Provides prognostic information
Confirmation of drug target inhibition
Validation of biomarkers predictive of response
Go vs. no-go signal for large adjuvant trials
Triaging of combinations to be tested in metastatic disease
Discovery of mechanisms of drug resistance