Table 1.

Properties of WT and mutant MEK1 alleles

MEK1 mutantsPhosphorylation dependencyRAF dependency
WTDependentDependent
Class ID67NDependentDependent
P124LDependentDependent
P124SDependentDependent
L177VDependentDependent
Class IIΔE51-Q58RegulatedRegulated
ΔF53-Q58RegulatedRegulated
E203KRegulatedRegulated
L177MRegulatedRegulated
C121SRegulatedRegulated
F53LRegulatedRegulated
K57ERegulatedRegulated
Q56PRegulatedRegulated
K57NRegulatedRegulated
Class IIIΔL98-I103IndependentIndependent
ΔI99-K104IndependentIndependent
ΔE102-I103IndependentIndependent
ΔI103-K104IndependentIndependent