Table 1.

Biochemical potency of BLU-667 and MKIs against activated RET mutants and fusion variants

Biochemical IC50, nmol/L
CompoundWT RETRET V804LRET V804MRET M918TCCDC6–RETVEGFR2
BLU-6670.40.30.40.40.435
Cabozantinib11451628342
Vandetanib43,5977267204
RXDX-10531881024717