Table 1.

Patient demographic information

CCF IDSexAgeRaceEthnicityFinal diagnosisNew diagnosis vs. recurrent diagnosisIDH1 statusATRX expressionp53 stainKi-67 stainMGMT promoter methylation
Patient 1Male38WhiteNonhispanicGBMNewWild-typeRetained5%70%Unmethylated
Patient 2Male44WhiteNonhispanicGBMNewWild-typeRetained5%70%Methylated
Patient 3Male60WhiteNonhispanicGBMRecurrentWild-typeRetained>80%>50%Unmethylated
Patient 4Male72WhiteNonhispanicGBMNewWild-typeRetained80%60%Unmethylated
Patient 5Male67WhiteNonhispanicGBMRecurrentWild-typeRetained10%30%Unmethylated
Patient 6Male63WhiteNonhispanicGBMNewWild-typeRetained20%40%Unmethylated
Patient 7Male63WhiteN/AGBMNewWild-typeRetained10%50%Unmethylated
Patient 8Male59WhiteNonhispanicGBMRecurrentWild-typeRetained>90%60%Unmethylated
NU IDSexAgeRaceEthnicityFinal diagnosisNew diagnosis vs. recurrent diagnosisIDH1 statusATRX expressionp53 stainKi-67 stainMGMT promoter methylation
Patient 1Female74WhiteNonhispanicGBMNewWild-type-25%Unmethylated
Patient 2Female85WhiteNonhispanicGBMNewWild-typeUnmethylated
Patient 3Female59WhiteNonhispanicGBMNewWild-typeRetained10%70%Unmethylated
Patient 4Female67WhiteNonhispanicGBMNewWild-typeRetained20%Unmethylated
Patient 5Female74WhiteNonhispanicGBMNewWild-typeUnmethylated
Patient 6Female53WhiteNonhispanicGBMNewWild-typeRetainedUnmethylated
Patient 7Female81WhiteNonhispanicGBMNewWild-typeRetained5%–7%50%Unmethylated
Patient 8Female68WhiteNonhispanicGBMNewWild-typeUnmethylated
Patient 9Female30WhiteNonhispanicGBMNewWild-typeRetained10%40%Unmethylated
Patient 10Female63WhiteNonhispanicGBMNewWild-typeUnmethylated
Patient 11Male69WhiteNonhispanicGBMNewWild-type25%–30%Unmethylated
Patient 12Male56WhiteNonhispanicGBMNewWild-typeRetained<10%40%Unmethylated
Patient 13Male63WhiteNonhispanicGBMNewWild-type30%Unmethylated
Patient 14Male77WhiteNonhispanicGBMNewWild-typeUnmethylated
Patient 15Male53WhiteNonhispanicGBMNewWild-typeUnmethylated
Patient 16Male62WhiteNonhispanicGBMNewWild-typeRetained70%40%Unmethylated
Patient 17Male72WhiteNonhispanicGBMNewWild-typeUnmethylated
Patient 18Male80WhiteNonhispanicGBMNewWild-typeRetained<5%40%Unmethylated
Patient 19Male61WhiteNonhispanicGBMNewWild-typeRetained5%25%Unmethylated
Patient 20Male54WhiteNonhispanicGBMNewWild-typeRetained10%20%Unmethylated
  • NOTE: Sex, age, race, ethnicity, diagnosis, recurrence, IDH1/ATRX expression, p53/Ki-67 staining and MGMT status of patient specimens used to assess MDSC accumulation [Cleveland Clinic Foundation (CCF) cohort] and IL1β expression [Northwestern University (NU) cohort].