Table 2.

Summary of the most common all-cause TEAEs occurring in ≥10% of the total population by grade and cycle

Cycle 1(n = 22)Cycle ≥2(n = 22)Total(N = 22)
n (%)Grade 1/2Grade 3/4Grade 1/2Grade 3/4Grade 1/2Grade 3/4
TEAEs
 Anemia6 (27.3)6 (27.3)2 (9.1)16 (72.7)018 (81.8)
 Neutropenia/decreased neutrophil count5 (22.7)8 (36.4)4 (18.2)11 (50.0)4 (18.2)12 (54.5)
 Fatigue8 (36.4)08 (36.4)2 (9.1)13 (59.1)2 (9.1)
 Nausea5 (22.7)1 (4.5)6 (27.3)1 (4.5)9 (40.9)2 (9.1)
 Thrombocytopenia/decreased platelet count4 (18.2)4 (18.2)7 (31.8)06 (27.3)4 (18.2)
 Back pain3 (13.6)05 (22.7)07 (31.8)0
 Pyrexia2 (9.1)05 (22.7)06 (27.3)0
 Diarrhea004 (18.2)1 (4.5)4 (18.2)1 (4.5)
 Headache4 (18.2)01 (4.5)05 (22.7)0
 Abdominal pain2 (9.1)1 (4.5)2 (9.1)03 (13.6)1 (4.5)
 Hypokalemia004 (18.2)04 (18.2)0
 Leukopenia/decreased white blood cell count03 (13.6)02 (9.1)04 (18.2)
 Vomiting1 (4.5)03 (13.6)1 (4.5)3 (13.6)1 (4.5)
 Constipation2 (9.1)01 (4.5)03 (13.6)0
 Decreased appetite1 (4.5)02 (9.1)03 (13.6)0
 Dyspnea1 (4.5)02 (9.1)03 (13.6)0
 Gastroesophageal reflux disease003 (13.6)03 (13.6)0
 Hypotension1 (4.5)1 (4.5)1 (4.5)02 (9.1)1 (4.5)
 Oropharyngeal pain2 (9.1)02 (9.1)03 (13.6)0
 Productive cough003 (13.6)03 (13.6)0
 Stomatitis1 (4.5)03 (13.6)03 (13.6)0