Table 1.

HLA types, mutations, and ATLAS responses for the research cohort

HLA haplotypesMutationsStimulatory responsesInhibitory responses
MHC class IMHC class IISNSCD8+CD4+CD8+CD4+
USO-004A 01:01, 02:01DPA1*01:03, 01:03; DPB1*04:01, 03:01;7001810%12%0%12%
B 08:01, 15:01DQA1*01:02, 01:02; DQB1*06:02, 04:02;
C 07:01, 04:01DRA1*01:01, 01:01; DRB1*15:01, 08:01
USO-007A 02:01, 11:01DPA1*01:03, 01:03; DPB1*04:02, 03:01;9711300%0%1%3%
B 35:01, 15:01DQA1*01:02, 01:02; DQB1*06:04, 05:02;
C 03:04, 04:01DRA1*01:01, 01:01; DRB1*13:02, 01:01
USO-008A 01:01, 24:02DPA1802:01, 02:01; DPB1*39:01, 04:01;170570%9%0%0%
B 08:01, 15:01DQA1*05:01, 05:01; DQB1*03:01, 02:01;
C 03:03, 07:01DRA1*01:01, 01:01; DRB1*11:01, 03:01
USO-010A 02:01, 02:05DPA1*01:03, 01:03; DPB1*03:01, 04:01;734970%0%0%1%
B 07:05, 50:01DQA1*02:01, 03:01; DQB1*03:02, 02:01;
C 06:02, 15:05DRA1*01:01, 01:01; DRB1*04:05, 07:01
USO-013A 03:01, 33:03DPA1*03:02, 03:02; DPB1*04:01, 17:01;7651761%3%0%0%
B 15:16, 35:01DQA1*01:02, 02:01; DQB1*05:01, 02:01;
C 04:01, 14:02DRA1*01:01, 01:01; DRB1*13:02, 07:01
USO-027A 11:01DPA1*01:03, 01:03; DPB1*02:01, 34:01;84172%5%2%0%
B 14:02, 51:01DQA1*01:03, 05:01; DQB1*06:01, 03:01;
C 03:03, 08:02DRA1*01:01, 01:01; DRB1*15:02, 11:01
USO-028A 24:02, 68:01DPA1*01:03, 01:03; DPB1*02:01, 04:01;9313192%5%2%3%
B 35:03, 51:01DQA1*01:03, 01:03; DQB1*06:11, 06:11;
C 04:01, 15:02DRA1*01:01, 01:01; DRB1*15:01, 13:01
USO-031A 02:01, 02:05DPA1*01:03, 01:03; DPB1*03:01, 02:01;2156921%25%5%4%
B 50:01, 51:01DQA1*01:03, 02:01; DQB1*06:03, 06:03;
C 06:02, 14:02DRA1*01:01, 01:01; DRB1*13:01, 07:01
USO-041A 01:01, 03:01DPA1*01:03, 01:03; DPB1*02:01, 04:01;2226335%0%1%5%
B 07:02, 08:01DQA1*01:02, 03:01; DQB1*06:02, 03:02;
C 07:01, 07:02DRA1*01:01, 01:01; DRB1*04:04, 15:01
Median700971%5%1%3%
  • Abbreviations: NS, nonsynonymous; S, synonymous.