Table 2.

Clinical characteristics of younger (<60 years) and older (≥60 years) Black and White patients with AML treated on the CALGB/Alliance study protocols

Younger patientsOlder patients
BlackWhiteBlackWhite
Characteristicsn = 72n = 777Pan = 23n = 467Pa
Age, years0.060.54
 Median41466970
 Range20–5917–5962–9260–89
Sex, n (%)0.810.40
 Male38 (53)424 (55)11 (48)267 (57)
 Female34 (47)353 (45)12 (52)200 (43)
Hemoglobin, g/dL0.090.19
 Median8.69.29.19.3
 Range2.3–13.23.1–25.16.3–11.93.0–15.0
Platelet count, ×109/L0.240.19
 Median56524260
 Range16–2794–6485–4264–989
WBC count, ×109/L0.660.75
 Median25.124.616.824.0
 Range0.4–308.80.6–560.01.4–155.90.4–450.0
Blood blasts, %0.250.35
 Median47566144
 Range0–980–994–910–99
BM blasts, %0.950.03
 Median64657966
 Range21–962–9917–990–99
Extramedullary involvement, n (%)17 (26)200 (27)1.000 (0)101 (23)0.01
2017 ELN risk group, n %0.270.13
 Favorable29 (40)381 (49)5 (22)143 (31)
 Intermediate16 (22)169 (22)3 (13)121 (26)
 Adverse27 (38)227 (29)15 (65)203 (43)
Year of diagnosis, n (%)0.600.84
 1986–199512 (17)103 (13)2 (9)60 (13)
 1996–200532 (44)382 (49)18 (78)324 (69)
 2005–201528 (39)292 (38)3 (13)83 (18)
Cytogenetic group, n (%)0.230.57
 Normal karyotype27 (38)401 (52)9 (39)235 (50)
 Complex karyotype8 (11)57 (7)6 (26)75 (16)
  Typical440258
  Atypical417417
 CBF-AML13 (18)108 (14)0 (0)0 (0)
  inv(16)(p13.1q22)77100
  t(8;21)(q22;q22)63700
 t(v;11)(v;q23)6 (8)44 (6)1 (4)15 (3)
 Other balanced rearrangements6 (8)61 (8)1 (4)24 (5)
 Unbalanced abnormalities in a noncomplex karyotype12 (17)106 (14)6 (26)118 (25)
  • Abbreviations: CBF, core binding factor; WBC, white blood cell.

  • aP values for categorical variables are from Fisher exact test. P values for continuous variables are from the Wilcoxon rank-sum test.